Relationship of Renal Function, Glomerular Uftrastructure and Slit Pore Count in Chronic Puromrcin Aminonuckoside Nephrosis

Abstract

Background and Design: In order to create massive proteinuria, puromycin-amin o nucleoside (PAN) is one of the most used models. Podocyte injury causes proteinuria. PAN rats' glomeruli show alterations like minimal change disease in humans, but the mechanism of PAN is not yet understood in total. We aimed to evaluate and show the relationship of renal function and the changes of the ultrastructu-re of the glomeruli, including the number of slit pores in puromycin-aminonucleoside induced chronic nephrosis.