The Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoietic Stem Cell Transplantation in Pediatric Patients with Leukemia

Abstract

Objective: Hematopoietic stem cell transplantation (HSCT) is an important therapy for hematological diseases. One of the most significant complications of HSCT is graft versus host disease (GVHD), and major histocompatibility complex (MHC) is well known to affect GVHD and graft rejection. This study aimed to examine the effect of human leukocyte antigens (HLA) on the incidence of GVHD development in patients with leukemia.