Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Tarih
2018
Yazar
Breen, Gerome
Boomsma, Dorret I.
Levinson, Douglas F.
Baune, Bernhard T.
Nelson, Elliot N.
Peyrot, Wouter J.
Van der Auwera, Sandra
Milaneschi, Yuri
Dolan, Conor V.
Madden, Pamela A. F.
Sullivan, Patrick F.
Strohmaier, Jana
Ripke, Stephan
Rietschel, Marcella
Nivard, Michel G.
Mullins, Niamh
Montgomery, Grant W.
Henders, Anjali K.
Heat, Andrew C.
Fisher, Helen L.
Dunn, Erin C.
Byrne, Enda M.
Air, Tracy A.
Depressive, Major
Grabe, Hans J.
Wray, Naomi R.
Penninx, Brenda W. J. H.
Martin, Nick G.
Lewis, Cathryn M.
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Özet
BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS 3 CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample.
Bağlantı
http://hdl.handle.net/20.500.12627/176642
https://doi.org/10.1016/j.biopsych.2017.09.009
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