In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Yazar
Tran-Dinh, Alexy
Castier, Yves
Guyard, Alice
Longrois, Dan
Silverstein, Adam M.
Norel, Xavier
Ozen, Gulsev
Amgoud, Yasmine
Senbel, Amira
Bouhadoun, Amel
Abdelazeem, Heba
Savane, Ines
Manikpurage, Hasanga D.
Mani, Salma
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Özet
Introduction: Prostacyclin (PGI(2)) is synthetized by PGI(2) synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI(2) signaling pathway are reduced in patients with pulmonary hypertension (PH).
Bağlantı
http://hdl.handle.net/20.500.12627/175412
https://doi.org/10.1016/j.plefa.2021.102321
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