Endemı̇k Centaurea Zaferı̇ı̇ Negaresh Bı̇tkı̇sı̇nı̇n Antı̇oksı̇dan Aktı̇vı̇tesı̇, Α- Amı̇laz ve ΑGlı̇kozı̇daz Enzı̇mlerı̇nı̇ İ ̇nhı̇be Edı̇cı̇ Özellı̇klerı̇nı̇n Belı̇rlenmesı

Abstract

Many species are belonging to the genus Centaurea, which the rate of endemism 61% in Turkey, used to treat many diseases traditionally among the people and thus the increasing bioactivity studies related to these species. Different extracts from Centaurea zaferii Negaresh plant used in this study were found to be rich in total phenolic (TPC) and flavonoid content (TFC), and the extracts were found to be strong in both in-vitro antioxidant tests and inhibition of diabetes-associated enzymes (α-amylase and α-glucosidase). It was determined that TPC (21,76 mg GAE/g) was higher in methanol extract, while in dichloromethane extract, TFC (489.74 mg RE/g) was higher, obtained by maceration. It was determined that dichloromethane extract was more effective in phosphomolybdenum (164.55 mg TE/g) antioxidant test and α-amylase (1073,71 mg ACE/g) inhibition, methanol extract in DPPH (6.688 mg TE/g), ABTS (33.28 mg TE/g), CUPRAC (61,71 mg TE/g), FRAP (82,22 mg TE/g) antioxidant tests, and α-glucosidase (1147.00 mg ACE/g) inhibition. As a result, further phytochemical studies are planned to determine the active compounds in C. zaferii Negaresh plant extracts' content and determine the different biological activities of these extracts besides enzyme inhibition and to be published in an international journal.