CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies

Yazar
DÜZOVA, ALİ
van der Zanden, Loes F. M.
van Rooij, Iris A. L. M.
Quaedackers, Josine S. L. T.
Nijman, Rien J. M.
Steffens, Martijn
Schaefer, Franz
Montini, Giovanni
Wuttke, Matthias
Jennings, Rachel
Hanley, Neil A.
Milmoe, Natalie J.
Winyard, Paul J. D.
Renkema, Kirsten Y.
Schreuder, Michiel F.
Roeleveld, Nel
Feitz, Wout F. J.
de Wall, Liesbeth L. L.
Bongers, Ernie M. H. F.
Kirchner, Marietta
Behnisch, Rouven
KARABAY BAYAZIT, AYSUN
ÇALIŞKAN, Salim
Obrycki, Lukasz
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Özet
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.
Bağlantı
http://hdl.handle.net/20.500.12627/174536
https://doi.org/10.1016/j.euros.2021.04.001
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