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dc.contributor.authorİŞÇİOĞLU, FUNDA
dc.contributor.authorBALDANE, SÜLEYMAN
dc.contributor.authorGokturk, Fatma
dc.contributor.authorKÖREZ, MUSLU KAZIM
dc.contributor.authorGonen, Mustafa Sait
dc.contributor.authorARIKOĞLU, HİLAL
dc.contributor.authorErkoc-Kaya, Dudu
dc.contributor.authorIpekci, Suleyman Hilmi
dc.identifier.citationARIKOĞLU H., Erkoc-Kaya D., Ipekci S. H. , Gokturk F., İŞÇİOĞLU F., KÖREZ M. K. , BALDANE S., Gonen M. S. , "Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population", MOLECULAR BIOLOGY REPORTS, 2021
dc.description.abstractType 2 diabetes (T2D) is a complicated public health problem in Turkey as well as worldwide. Genome-wide approaches have been guiding in very challenging situations, such as the elucidation of genetic variations underlying complex diseases such as T2D. Despite intensive studies worldwide, few studies have determined the genetic susceptibility to T2D in Turkish populations. In this study, we investigated the effect of genes that are strongly associated with T2D in genome-wide association (GWA) studies, including MTNR1B, CDKAL1, THADA, ADAMTS9 and ENPP1, on T2D and its characteristic traits in a Turkish population. In 824 nonobese individuals (454 T2D patients and 370 healthy individuals), prominent variants of these GWA genes were genotyped by real-time PCR using the LightSNiP Genotyping Assay System. The SNP rs1387153 C/T, which is located 28 kb upstream of the MTNR1B gene, was significantly associated with T2D and fasting blood glucose levels (P < 0.05). The intronic SNP rs10830963 C/G in the MTNR1B gene was not associated with T2D, but it was associated with fasting blood glucose, HbA1C and LDL levels (P < 0.05). The other important GWA loci investigated in our study were not found to be associated with T2D or its traits. Only the SNP rs1044498 (A/C variation) in the ENPP1 gene was determined to be related to fasting blood glucose (P < 0.05). Our study suggests, consistent with the literature, that the MTNR1B locus, which has a prominent role in glucose regulation, is associated with T2D development by affecting blood glucose levels in our population.
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectYaşam Bilimleri
dc.subjectLife Sciences
dc.subjectStructural Biology
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.titleType 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
dc.contributor.departmentSelçuk Üniversitesi , ,

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