Small Molecule, Multimodal, [F-18]-PET and Fluorescence Imaging Agent Targeting Prostate-Specific Membrane Antigen: First-in-Human Study

Tarih
2021
Yazar
Guo, Hua
Chen, Nandi
Harmsen, Stefan
SÖNMEZOĞLU, Kerim
Lundon, Dara J.
Oklu, Rahmi
Ting, Richard
Tewari, Ashutosh
Akin, Oguz
SAYMAN, Haluk Burcak
Aras, Omer
DEMİRDAĞ, Çetin
Kommidi, Harikrishna
Pavlova, Ina
AYGÜN, Aslan
KARAYEL, Emre
Pehlivanoglu, Huseyin
YEYİN, Nami
Kyprianou, Natasha
Üst veri
Tüm öğe kaydını göster
Özet
A number of radioactive tracers are currently being actively examined to image prostate-specific membrane antigen positive (PSMA+) tumors, especially in primary and recurrent prostate cancer. We report a first-in-human study of [18F]-BF3-Cy3-ACUPA by determining its safety, biodistribution, radiation dosimetry, and feasibility of tumor detection by preoperative positron emission tomography, as well as intraoperative fluorescence imaging, in patients with PSMA+ tumors.
Bağlantı
http://hdl.handle.net/20.500.12627/168844
https://doi.org/10.1016/j.clgc.2021.03.011
Koleksiyonlar