P15 peptide stimulates chondrogenic commitment and endochondral ossification

Abstract

Purpose The synthetic 15 amino acid biomimetic peptide sequence (P15) derived from a region of the alpha (alpha)-1 chain of collagen I, has been shown to promote alpha 2 integrin activation and enhance intramembranous ossification. In this study, we ask if the P15 peptide also enhances bone formation through endochondral ossification, and determine if direct binding of alpha 2 integrin with P15 mediates integrin activation.