Tuftsin protects against diabetes induced by multiple low-dose streptozotocin in mice

Abstract

The effects of Tuftsin, an immunomodulator agent, in experimental diabetes induced mice was studied. Injecting 40 mg STZ per kg of body weight for 5 consecutive days produced autoimmune diabetes. Treatment with 10 mu g/mouse of Tuftsin did not prevent hyperglycemia. On the other' hand, 25 mu g/mouse of Tuftsin prevented diabetes. These results indicate that high dose Tuftsin seems to be effective in preventing hyperglycemia in diabetic mice and appear to suggest that Tuftsin has an immunomodulatory (suppressive) activity in these animals.