Effects Of Darbepoetin Alpha on Brain Tissue Oxidative Stress in Experimental Ethanol Administration

Abstract

Objectives: The hyperglycosylated erythropoietin analogue darbepoetin alpha (alpha) has longer half-life and higher in vivo activity. There is no data about the effects of darbepoetin-alpha on ethanol-induced oxidative stress. In this study, we investigated the effects of darbepoetin-alpha on brain tissue oxidant/antioxidant status and nitric oxide levels in experimental ethanol administration.