Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate
Tarih
2008Yazar
Elferink, Ronald P. J. Oude
Pala, Zeliha
de Waart, Dirk R.
van de Wetering, Koen
Schinkel, Alfred H.
Vlaming, Maria L. H.
van Esch, Anita
Wagenaar, Els
van Tellingen, Olaf
Üst veri
Tüm öğe kaydını gösterÖzet
Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.
Koleksiyonlar
- Makale [92796]