EFFECTS OF ERYTHROPOIETIN ON NITRIC OXIDE SYNTHASE TYPES IN THE HIPPOCAMPUS AND FRONTAL CORTEX IN PTZ-INDUCED SEIZURES IN RATS

Abstract

Objective: Nitric oxide, an important mediator in the dysfunctions of learning-memory and epileptogenesis, is formed by nitric oxide synthase (NOS) in neuronal cells in many areas of the brain, primarily the hippocampus. It is has been shown that erythropoietin (EPO) has neuroprotective and antiepileptic effects. The aims of this study was to investigate the effects of EPO pre-treatment on convulsions and NOS species in the hippocampus and frontal cortex in pentylenetetrazole (PTZ)-induced generalized seizure model.