Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607
Tarih
2011Yazar
Breeman, Wout A. P.
Ocak, Meltem
Sosabowski, Jane K.
Reubi, Jean Claude
Decristoforo, Clemens
Helbok, Anna
Rangger, Christine
Peitl, Petra Kolenc
Nock, Berthold A.
Morelli, Giancarlo
Eek, Annemarie
Üst veri
Tüm öğe kaydını gösterÖzet
Stability of radiolabelled cholecystokinin 2 (CCK2) receptor targeting peptides has been a major limitation in the use of such radiopharmaceuticals especially for targeted radionuclide therapy applications, e.g. for treatment of medullary thyroid carcinoma (MTC). The purpose of this study was to compare the in vitro stability of a series of peptides binding to the CCK2 receptor [selected as part of the COST Action on Targeted Radionuclide Therapy (BM0607)] and to identify major cleavage sites.
Koleksiyonlar
- Makale [92796]