Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum
Tarih
2011Yazar
Tinari, Nicola
Okyar, Alper
La Sorda, Rosanna
Iacobelli, Stefano
Levi, Francis
Piccolo, Enza
Ahowesso, Constance
Filipski, Elisabeth
Hossard, Virginie
Guettier, Catherine
Üst veri
Tüm öğe kaydını gösterÖzet
Background: ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum mucosa, and further assess whether genetic background or sex modify this relation.
Koleksiyonlar
- Makale [92796]