Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma

Date
2014
Author
Erdem, Merve
Erdem, Selçuk
Telci, Dilek
Sanli, Oner
Kilicaslan, Isin
Sak, Halis
Sahin, Fikrettin
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Abstract
Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through 131 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TG.M2. ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RUC).
URI
http://hdl.handle.net/20.500.12627/146609
https://doi.org/10.1016/j.urolonc.2012.08.022
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