DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

Abstract

An iridoid glucoside reptoside ( 1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds ( 24S)-24-ethylcholesta-5,25-dien-3 beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.