Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease
Tarih
2005Yazar
Saruhan-Direskeneli, G
Yilmaz, V
Hajeer, AH
Uyar, FA
Gul, A
Duymaz-Tozkir, J
Üst veri
Tüm öğe kaydını gösterÖzet
Objective. Genetic susceptibility to Behcet's disease (BD) is well documented for HLA-B51; however, contribution of other genetic polymorphisms is estimated to be substantial. Interleukin 8 (IL-8), a potent chemoattractant for neutrophils, has been found to be elevated in BD serum, and the serum concentrations correlate with disease activity. Novel polymorphisms in IL-8 (CXCL8) and in one of its receptors, CXCR2 gene, may have a role in enhanced IL-8 activity in BD.
Koleksiyonlar
- Makale [92796]