Osteointegration of a Bisphenol-a-Glycidyl-Dimethacrylate Composite and Its Use in Anterior Skull Base Defects: An Experimental Study in an Experimental Design Model of Cerebrospinal Fluid Leak

Abstract

Object: Promising clinical results were reported in watertight closure of anterior skull base defects (ASBDs) with bisphenol-a-glycidyl-dimethacrylate (bis-GMA)-based materials to prevent the cerebrospinal fluid leaks. However, interrelation of these materials with surrounding bones in histologic level, referred to as the osteo-integration, has not been reported in the anterior skull base. In addition, an illustrative case with an ASBD that was repaired using a bis-GMA composite has been presented.