Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations
Tarih
2007Yazar
GERVAIS, Thibaut
ABSI, Lena
CANOSSI, Angelica
CHHAYA, Sonal
CROWLEY, John
DOLSTRA, Harry
ELIAOU, Jean-Francois
ELLIS, Tom
ENCZMANN, Juergen
FASANO, Maria E.
GORODEZKY, Clara
KIRCHER, Brigitte
LAURIN, David
LEFFELL, Mary S.
LOISEAU, Pascale
MALKKI, Mari
MARKIEWICZ, Miroslaw
MARTINETTI, Miryam
MARUYA, Etsuko
MEHRA, Narinder
OUDSHOORN, Machteld
PEREIRA, Noemi
RANI, Rajni
SERGEANT, Ruhena
THOMSON, Jackie
TRAN, Thuong Hien
TURPEINEN, Hannu
YANG, Kuo-Liang
ZUNEC, Renata
GOULMY, Els
CARRINGTON, Mary
DE KNIJFF, Peter
Oguz, Fatma
SPIERINGS, Eric
HENDRIKS, Matthijs
Üst veri
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Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft- versus-host disease, and in the curative graft-versus- tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.
Koleksiyonlar
- Makale [92796]