Synthesis and anticonvulsant activity of some new arylidenehydrazides and 4-thiazolidinones

Abstract

A number of N,N'-bis(arylidene)mono(1-methylpropyl)malonic acid dihydrazides (3a-c), 1,1-bis[[(2-aryl-4-thiazolidinone-3-yl)amino]carbonyl]-2-methylbutanes (4a-e), and 1,1-bis[[3-alkyl/aryl-4-thiazolidinone-2-yl)hydrazono]carbonyl]-2-methylbutanes (6a-i) have been synthesized, characterized and evaluated for anticonvulsant activity. All tested compounds showed significant activity (10 to 60% protection) against pentylenetetrazole induced seizures.