Immunosuppressive therapy in lupus nephritis - The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide

Date
2002
Author
ABRAMOVICZ, D
HOUSSIAU, FA
VASCONCELOS, C
D'CRUZ, D
SEBASTIANI, GD
GARRIDO, ED
DANIELI, MG
BLOCKMANS, D
MATHIEU, A
DIRESKENELI, H
GALEAZZI, M
LEVY, Y
PETERA, P
POPOVIC, R
PETROVIC, R
SINICO, RA
CATTANEO, R
FONT, J
DEPRESSEUX, G
COSYNS, JP
CERVERA, R
Gul, Ahmet
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Abstract
Objective. Glomerulonephritis is a severe manifestation of systemic lupus erythematosus (SLE) that is usually treated with an extended course of intravenous (IV) cyclophosphamide (CYC). Given the side effects of this regimen, we evaluated the efficacy and the toxicity of a course of low-dose IV CYC prescribed as a remission-inducing treatment, followed by azathioprine (AZA) as a remission-maintaining treatment.
URI
http://hdl.handle.net/20.500.12627/114959
https://doi.org/10.1002/art.10461
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