Immunohistochemical detection of p53 protein in rhabdomyosarcoma: Association with clinicopathological features and outcome

Abstract

Purpose: Alteration in the p53 tumor suppressor gene is the most common tumor specific genetic change identified in most major cancer types including rhabdomyosarcomas. To investigate the overexpression of p53 and its relation to clinical features and outcome in patients with rhabdomyosarcoma (RMS), an immunocytochemical study was performed.