Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene increases the risk of developing Graves' disease

Tarih
2014
Yazar
Vural, Pervin
Baki, Merve
KARADAG, Berrin
Uysal, Mujdat
Dogru-Abbasoglu, Semra
OZDERYA, Aysenur
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Özet
Background: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD.
Bağlantı
http://hdl.handle.net/20.500.12627/107886
https://doi.org/10.1016/j.intimp.2014.03.019
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