Effects of iloprost on lipid peroxidation parameters in cerebral hypoperfusion model induced by right common carotid artery occlusion

Abstract

Our aim was to study effects of iloprost on lipid peroxidation parameters in cerebral hypoperfusion model induced by right common carotid artery occlusion. The rats were divided into 4 weight-matched groups. Sham-operated group (S) (n=10); Hypoperfused (H) (n=10); Early iloprost administered after hypoperfusion (HE) (n= 10); Late iloprost administered after hypoperfusion (HQ (n=10). Plasma MDA levels of H, HE and HL groups were significantly higher than S group (respectively p<0.001. p<0.05. p<0.001). Values of intraerythrocytic Cu-Zn SOD activity of H. HE and HL groups were significantly higher than those of S group (p<0.001). The right hemisphere tissue MDA levels of S group were highest (P<0.05). HE group right hemisphere Cu-Zn SOD activity was higher than other groups, on the other hand HL group right hemisphere Cu-Zn SOD activity significantly lower than other groups (p<0.001). Our findings revealed that the early iloprost treatment might be protected the brain tissue from oxidative damage.