Painful Polyneuropathy in Poems Syndrome with Multicentric Castleman Disease: A Case Report

Abstract

POEMS is a rare syndrome which is associated with monoclonal plasma cell dyscrasia. Although polyneuropathy is one of the major criteria, Castleman disease is a minor criteria. Herein, we report a patient with a painful sensory-motor polyneuropathy, who is diagnosed with POEMS syndrome and also has multicentric Castleman disease. Monoclonal gammopathy presenting with painful polyneuropathy can be associated with POEMS syndrome. Keeping this association in mind would decrease morbidity in patients who probably have a good prognosis. (Archives of Neuropsychiatry 2011; 48: 211-4)