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Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma.

Aktas, Esin; Bonavıda, Benjamin; Uslu, Atilla; Ozdemır, Aysegul; Öktem, Gülperi; Erguven, Mine; Bilir, Ayhan (2008)

Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for ...

SET oncogene is upregulated in pediatric acute lymphoblastic leukemia

Emrence, Zeliha; Akbiyik, Meral; Agaoglu, Leyla; Unuvar, Aysegul; Ozbek, Ugur; Abaci, Neslihan; Karakas, Zeynep; Grosveld, Gerard; Kandilci, Ayten; Ekmekci, Sema Sirma; Ekmekci, Cumhur G.; Ustek, Duran; Devecioglu, Omer; Gulec, Cagri (2012)

Aims and background. The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive ...